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Hh-Dose, Short-Course Levofloxacin for Community-Acquired. This randomized, double-blind, noninferiority study was desned to demonstrate that a single 2.0-g oral dose of a novel microsphere formulation of azithromycin was at least as effective as 7 days of levofloxacin, 500 mg/day, in the treatment of adult patients with mild to moderate community-acquired pneumonia (Fine classes I, II, and III). The value and 24-h AUC achieved after a single 2.0-g dose of azithromycin microspheres are two and three times hher, respectively, than those achieved with the first dose, 500 mg, of either the 3- or 5-day immediate-release regimens that are currently approved in the United States and abroad. Strategies for the empirical treatment of community-acquired pneumonia CAP. The protocol was approved by the participating institutions' institutional review.
How should aspiration pneumonia be treated? - Luoroquinolones continue to become an increasingly important class of drugs for treating a wide range of infections, with ofloxacin being one of the most commonly used of these compounds (1). Other very favourable pharmacokinetic effects include an 80-85% renal excretion with virtually no metabolites, a plasma half-life of six to seven hours and a two to three hour post antibiotic effect allowing the physician to maintain therapeutic levels with once-daily dosing (Table 1). The 2007 IDSA community-acquired pneumonia guidelines offer the following unreferenced and poorly substantiated comments regarding.
Hospital-acquired pneumonia - Management - Approach - Best. Injection is 250 mg or 500 mg administered by slow infusion over 60 minutes every 24 hours or 750 mg administered by slow infusion over 90 minutes every 24 hours, as indicated by infection and described in Table 1. A pre-specified antibiotic protocol in patients with a new diagnosis of HAP is not. ceftazidime, imipenem/cilastatin, meropenem, levofloxacin.
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