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Fibromyalgia Medication Analgesics, Antianxiety Agents, Skeletal. Medication summary Always combine pharmacologic approaches with nonpharmacologic therapy in the treatment of fibromyalgia (FM), especially stress management, aerobic exercise, and, in some cases, psychotherapy. Tricyclic antidepressants (TCAs) are of proven benefit. Fibromyalgia is currently understood to be a disorder of central pain processing or a syndrome of central sensitivity. Clauw describes the syndrome as a.