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Swallowing & Esophageal Disorders Surgery Drs. Mason & Raja 04. Therapeutic Class: Gastric Acid Secretion Inhibitor Pharmacologic Class: Esomeprazole Esomeprazole is used to treat conditions where there is too much acid in the stomach. Three times this past year I have had to take Nexium twice a day to calm. a less invasive form of anti-reflux surgery and its cons are that it may.